Oncology Medical News about thrombocythemia

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In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm
Blood, 06/22/09

Lambert JR et al. - JAK2 mutant-positive erythroid colonies with either X-allele inactivated were detected, demonstrating they could not have arisen from a common clonal precursor. These results indicate that at least two independent JAK2-V617F events occur commonly in ET patients, and they may arise on a polyclonal background. The presence of a JAK2 mutation in ET patients should not, therefore, be equated with a malignant disease.

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A latent form of essential thrombocythemia presenting as portal cavernoma
World Journal of Gastroenterology, 11/18/09 Relevance Score: 87%%

The influence of low-dose aspirin and hydroxyurea on platelet-leukocyte interactions in patients with essential thrombocythemia
Blood Coagulation & Fibrinolysis, 11/03/09 Relevance Score: 85%%

MicroRNA expression profiling of megakaryocytes in primary myelofibrosis and essential thrombocythemia
Platelets, 10/02/09 Relevance Score: 85%%

Src tyrosine kinase pre-activation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera
Blood, 11/25/09 Relevance Score: 84%%

The JAK2 46/1 haplotype confers susceptibility to essential thrombocythemia regardless of JAK2V617F mutational status—clinical correlates in a study of 226 consecutive patients
Leukemia, 10/27/09 Relevance Score: 84%%