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See Latest ArticlesEpigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer
International Journal of Cancer, 06/25/09
Nicholson LJ et al. - The data establish epigenetic inactivation of ASS1 as a determinant of response to platinum chemotherapy and imply that transcriptional silencing of ASS1 contributes to treatment failure and clinical relapse in ovarian cancer. The collateral sensitivity of cells lacking endogenous ASS1 to arginine depletion suggests novel therapeutic strategies for the management of relapsed ovarian cancer.
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Today in Basic Science/Genetics...keeping you current
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Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression
Cellular Oncology, 12/07/09
Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients
Cellular Oncology, 12/07/09
Differential apoptotic response of human cancer cells to organoselenium compounds
Cancer Chemotherapy and Pharmacology, 12/07/09
Today in Gynecologic Oncology...keeping you current
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Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression
Cellular Oncology, 12/07/09
Oestrogen receptor 1 mRNA is a prognostic factor in ovarian cancer patients treated with neo-adjuvant chemotherapy: determination by array and kinetic PCR in fresh tissue biopsies
Endocrine-Related Cancer, 12/07/09
Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue
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