Oncology Medical News about death-associated protein 3;thyroid oncocytic tumors

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Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours
British Journal of Cancer, 06/19/09

Jacques C et al. - In a study to assess whether human death-associated protein 3 (hDAP3) is overexpressed in human thyroid oncocytic tumours, it was found that ELK1 and estrogen-related receptor alpha (ESRRA) may be considered potential regulators of DAP3 gene expression. DAP3 may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis.

Methods

A search through publicly available microarray data sets showed 337 genes potentially coregulated with the DAP3 gene.
Promoter sequences of these 337 genes and 70 out of 85 mitochondrial ribosome genes were analysed in silico with the DAP3 gene promoter sequence.
Mitochondrial role of DAP3 was also investigated in the thyroid tumours presenting various mitochondrial contents.

Results

The study revealed 9 transcription factors presenting enriched motifs for these gene promoters, 5 of which are implicated in cellular growth (ELK1, ELK4, RUNX1, HOX11-CTF1, TAL1-ternary complex factor 3) and 4 in mitochondrial biogenesis (nuclear respiratory factor-1 [NRF-1], GABPA, PPARG-RXRA, and estrogen-related receptor alpha [ESRRA]).
An independent microarray data set showed the overexpression of ELK1, RUNX1, and ESRRA in the thyroid oncocytic tumours.
Exploring the thyroid tumours, DAP3 mRNA and protein expression is upregulated in tumours presenting a mitochondrial biogenesis compared with the normal tissue.
ELK1 and ESRRA were also showed upregulated with DAP3.

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