Your Article Summary
See Latest ArticlesMacrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma
Journal of Clinical Oncology, 06/18/09
Jensen TO et al. - In a study to evaluate the prognostic role of soluble CD163 (sCD163) in serum and macrophage infiltration in primary melanomas from pts with American Joint Committee on Cancer (AJCC) stage I/II melanoma, it was shown that both serum levels of sCD163 and the presence of CD68+ macrophage infiltration at the tumor invasive front are independent predictors of survival in AJCC stage I/II melanoma. CD163+ cell infiltration in tumor stroma may be predictive of survival.
Methods- Serum samples from 227 pts with stage I/II melanoma obtained before definitive surgery (baseline) and during 5 yrs of follow-up were analyzed for sCD163 by enzyme-linked immunosorbent assay.
- Excised formalin-fixed, paraffin-embedded primary melanomas from 190 pts were available for immunohistochemical analyzes of CD163+ and CD68+ macrophage infiltration.
- They were estimated semiquantitatively in 3 different tumor compartments: tumor nests, tumor stroma, and at the invasive front of the tumor.
- Serum sCD163 treated as an updated continuous covariate as well as the baseline value were analyzed together with the covariate's ulceration and thickness in a Cox proportional hazards model.
- sCD163 was an independent prognostic factor for overall survival (OS).
- Melanomas with dense CD163+ macrophage infiltration in tumor stroma and CD68+ macrophage infiltration at the invasive front were associated with poor OS independent of thickness and ulceration.
Related Articles
Loss of SNF5 expression correlates with poor patient survival in melanoma
Clinical Cancer Research, 10/12/09
Relevance Score: 97%
Slow-growing melanoma: a dermoscopy follow-up study
British Journal of Dermatology, 10/05/09
Relevance Score: 93%
Dormancy of metastatic melanoma
Pigment Cell & Melanoma Research, 11/11/09
Relevance Score: 91%
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma
Journal of Investigative Dermatology, 11/03/09
Relevance Score: 91%
KIT as a Therapeutic Target in Melanoma
Journal of Investigative Dermatology, 10/23/09
Relevance Score: 90%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Efficacy of plasma vascular endothelial growth factor in monitoring first-line chemotherapy in patients with advanced non-small cell lung cancer
BMC Cancer, 12/06/09
SULT1A1 R213H polymorphism and breast cancer risk: A meta-analysis based on 8,454 cases and 11,800 controls
Breast Cancer Research and Treatment, 12/06/09
Applicability of IG/TCR gene rearrangements as targets for minimal residual disease assessment in a population-based cohort of Swedish childhood acute lymphoblastic leukaemia diagnosed 2002-2006
European Journal of Haematology, 12/06/09
Today in Dermatologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
JWA regulates melanoma metastasis by integrin alphaVbeta3 signaling
Oncogene, 12/04/09
Immunocryosurgery for basal cell carcinoma: results of a pilot, prospective, open-label study of cryosurgery during continued imiquimod application
Journal of the European Academy of Dermatology and Venereology, 12/02/09
Self-reported screening for skin cancer in Austria
European Journal of Dermatology, 12/02/09