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Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma
Journal of Clinical Oncology, 06/18/09

Jensen TO et al. - In a study to evaluate the prognostic role of soluble CD163 (sCD163) in serum and macrophage infiltration in primary melanomas from pts with American Joint Committee on Cancer (AJCC) stage I/II melanoma, it was shown that both serum levels of sCD163 and the presence of CD68+ macrophage infiltration at the tumor invasive front are independent predictors of survival in AJCC stage I/II melanoma. CD163+ cell infiltration in tumor stroma may be predictive of survival.

Methods

Serum samples from 227 pts with stage I/II melanoma obtained before definitive surgery (baseline) and during 5 yrs of follow-up were analyzed for sCD163 by enzyme-linked immunosorbent assay.
Excised formalin-fixed, paraffin-embedded primary melanomas from 190 pts were available for immunohistochemical analyzes of CD163+ and CD68+ macrophage infiltration.
They were estimated semiquantitatively in 3 different tumor compartments: tumor nests, tumor stroma, and at the invasive front of the tumor.

Results

Serum sCD163 treated as an updated continuous covariate as well as the baseline value were analyzed together with the covariate's ulceration and thickness in a Cox proportional hazards model.
sCD163 was an independent prognostic factor for overall survival (OS).
Melanomas with dense CD163+ macrophage infiltration in tumor stroma and CD68+ macrophage infiltration at the invasive front were associated with poor OS independent of thickness and ulceration.

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