Oncology Medical News about accelerated partial-breast irradiation;conventional whole-breast radiotherapy;early breast cancer

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Accelerated partial-breast irradiation vs conventional whole-breast radiotherapy in early breast cancer: A case-control study of disease control, cosmesis, and complications
Journal of Cancer Research and Therapeutics, 06/19/09

Wadasadawala T et al. - In a study to compare disease control, cosmesis, and complications in pts with early breast cancer (EBC) undergoing accelerated partial-breast irradiation (APBI) using multicatheter interstitial brachytherapy vs those receiving conventional whole breast radiotherapy (WBRT), this study revealed equivalent locoregional and distant disease control in the 2 groups. APBI offered better overall cosmetic outcome, though at the cost of a slight increase in mild breast fibrosis and telangiectasias.

Methods

Women with EBC fulfilling the American Brachytherapy Society (ABS) criteria were selected as cases if treated with APBI or as controls if offered WBRT.
APBI pts were treated with high-dose-rate brachytherapy (HDR) to a dose of 34 Gy/10#/6-8 days.
WBRT was delivered to the whole breast to a dose of 45 Gy/25# followed by tumor bed boost, either with electrons (15 Gy/6#) or interstitial brachytherapy (HDR 10 Gy/1#).

Results

At median follow-up of 43.05 mos in APBI and 51.08 mos in WBRT, there was no difference in overall survival (OS), disease-free survival (DFS), late arm edema, and symptomatic fat necrosis between the 2 groups.
APBI resulted in increase in mild breast fibrosis at the tumor bed.
Telangiectasias were observed in 3 pnts of the APBI group.
Cosmetic outcome was significantly better in the APBI group vs the WBRT group.

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