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sFRP1 promoter methylation is associated with persistent Philadelphia chromosome in chronic myeloid leukemia
Leukemia Research, 06/19/09
Pehlivan M et al. - sFRP1 promoter methylation may indicate a genetically more unstable form of disease resistant to therapy and provide a key biological difference in therapy resistant patients, in addition to a possible mechanism for the observed activation of canonical Wnt signaling in CML.
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