Oncology Medical News about high grade osteosarcoma of the extremities;metastatic to the lung;surgery; chemotherapy

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High-grade osteosarcoma of the extremities metastatic to the lung: Long-term results in 323 patients treated combining surgery and chemotherapy, 1985–2005
Surgical Oncology, 06/19/09

Briccoli A et al. - In a study of high-grade osteosarcoma of the extremities metastatic to the lung, it was concluded that in pts with recurrent resectable pulmonary metastases from high-grade osteosarcoma treated with adjuvant or neoadjuvant chemotherapy, thoracotomy should always be considered regardless of the number of previous lung relapses and the number of secondary pulmonary lesions.

Methods

323 pts, 88 with resectable lung metastases at diagnosis and 235 with localized disease at presentation who relapsed with lung metastases, were treated.

Results

498 lung surgeries and 607 thoracotomies were performed.
5-yr overall survival was 37%.
Final outcome was significantly related to presence or absence of metastasis, time of first relapse and presence of local recurrences.
According to stage of disease, the rate of a 5-yr event-free survival (EFS) was 36% for pts with localized disease who later relapsed and 9% for pts with resectable lung metastases at presentation.
There were no differences in EFS between pts who underwent 2 or 3 thoracotomies and pts who had 4 or 5 thoracotomies (7.5 vs 18.7%).

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