Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesCaveolin-1 tumor-promoting role in human melanoma
International Journal of Cancer, 06/16/09
Felicetti F et al. - In a study to investigate Caveolin-1 (Cav-1) expression and function in a panel of melanomas, a secreted fraction was detected of Cav-1 associated with cell released microvesicular particles able to stimulate in vitro anchorage independence, migration and invasion in a paracrine/autocrine fashion and, competent to convey metastatic asset from the donor melanoma to the less aggressive recipient cell line. A direct correlation between Cav-1 levels, the amount of microvesicles released in the culture medium, and MMP-9 expression was also observed.
Methods- Cav-1 expression and function was investigated in a panel of melanomas, finding its expression in all the cell lines.
- The exception was the primary vertical melanoma cell line, WM983A, characterized by the lack of Cav-1, and then utilized as a recipient for Cav-1 gene transduction to address a series of functional studies.
- The alleged yet controversial role of phospho (Ph)-Cav-1 on cell regulation was also tested by transducing the nonphosphorylatable Cav-1Y14A mutant.
- Wild-type Cav-1, but not mutated Cav-1Y14A, increased tumorigenicity as indicated by enhanced proliferation, migration, invasion, and capacity of forming foci in semisolid medium.
- Cav-1 silencing inhibited melanoma cell growth reducing some of the typical traits of malignancy.
Related Articles
Loss of SNF5 expression correlates with poor patient survival in melanoma
Clinical Cancer Research, 10/12/09
Relevance Score: 69%
Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression
Modern Pathology, 11/11/09
Relevance Score: 67%
The role of human endogenous retroviruses in melanoma
British Journal of Dermatology, 10/05/09
Relevance Score: 67%
Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma
Clinics in Dermatology, 11/17/09
Relevance Score: 65%
Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts
Cancer Research, 10/21/09
Relevance Score: 65%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Decreased expression of KLF6 and its significance in gastric carcinoma
Medical Oncology, 12/17/09
Fas Ligand (FasL, Apo-1L/CD95L) Expression and Clinical Outcome in Papillary Microcarcinoma and Papillary Thyroid Carcinomas with Diameter Smaller than 1.5 Centimeters
Experimental and Clinical Endocrinology & Diabetes, 12/16/09
Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue
Oral Oncology , 12/16/09
Today in Dermatologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
Human Pathology, 12/16/09
Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays
Human Pathology, 12/16/09
MK2 regulates the early stages of skin tumor promotion
Carcinogenesis, 12/16/09
Sponsor
Article Search
Sponsor
Sponsor