Oncology Medical News about human melanoma;Caveolin-1 tumor promoting role

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Caveolin-1 tumor-promoting role in human melanoma
International Journal of Cancer, 06/16/09

Felicetti F et al. - In a study to investigate Caveolin-1 (Cav-1) expression and function in a panel of melanomas, a secreted fraction was detected of Cav-1 associated with cell released microvesicular particles able to stimulate in vitro anchorage independence, migration and invasion in a paracrine/autocrine fashion and, competent to convey metastatic asset from the donor melanoma to the less aggressive recipient cell line. A direct correlation between Cav-1 levels, the amount of microvesicles released in the culture medium, and MMP-9 expression was also observed.

Methods

Cav-1 expression and function was investigated in a panel of melanomas, finding its expression in all the cell lines.
The exception was the primary vertical melanoma cell line, WM983A, characterized by the lack of Cav-1, and then utilized as a recipient for Cav-1 gene transduction to address a series of functional studies.
The alleged yet controversial role of phospho (Ph)-Cav-1 on cell regulation was also tested by transducing the nonphosphorylatable Cav-1Y14A mutant.

Results

Wild-type Cav-1, but not mutated Cav-1Y14A, increased tumorigenicity as indicated by enhanced proliferation, migration, invasion, and capacity of forming foci in semisolid medium.
Cav-1 silencing inhibited melanoma cell growth reducing some of the typical traits of malignancy.

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