Oncology Medical News about senitenel lymph node-positive brest cancer;prediction of nonsentinel lymph node metastasis

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Assessment of the performance of the Stanford Online Calculator for the prediction of nonsentinel lymph node metastasis in sentinel lymph node-positive breast cancer patients
Cancer, 06/15/09

Scow JS et al. – Study demonstrates that despite using only 3 variables, the Stanford nomogram appears to perform on a par with, but not better than, the Memorial Sloan-Kettering Cancer Center (MSKCC) and Mayo nomograms. Further validation in other patient populations is needed.

Methods

An evaluation of the Stanford nomogram to predict the likelihood of NSLN metastasis using only 3 variables:
- Primary tumor size
- SLN metastasis size, and
- Angiolymphatic invasion status
  This was compared with Mayo and MSKCC nomograms
464 BCa pts with SLN metastasis who underwent completion axillary lymph node dissection at the Mayo Clinic
AUC was calculated for each model
Mean probabilities of pts with and w/o NSLN metastasis were compared
Pts with 5%, 10%, and 100% NSLN metastasis probabilities were examined

Results

AUCs of the Stanford, MSKCC, and Mayo models were 0.72, 0.74, and 0.77, respectively
Mean Stanford probabilities for pts with and w/o NSLN metastasis were 0.75 and 0.50, respectively
False-negative rates for pts with a Stanford probability of 5% and 10% were 0% and 13%, respectively
Of the pts with a Stanford probability of 100%, 26% did not have NSLN metastasis