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Charalambous MP et al. - These data suggest that in these cells COX-2 induction may be mediated through activation of the canonical NF-kB pathway. Finally, the lack of association between COX-2, NF-kB-p65 or IKK alpha in stromal cells with the clinical severity of colorectal cancer as determined by Duke's stage, suggests that COX-2, NF-kB-p65 and IKK alpha expression are possibly early post-initiation events, which could be involved in tumour progression.

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