Oncology Medical News about soft tissue sarcomas;risk factors

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Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases
Sarcoma, 06/11/09

Penel N et al. - In a trial to estimate the frequency of some particular etiological factors among 658 pts with soft tissue sarcomas, it was shown that the frequency of underlying genetic syndrome which may predispose to soft tissue sarcomas could be higher than previously reported.

Methods

A prospective descriptive study was carried out to estimate the frequency of some particular etiological factors among 658 pts with soft tissue sarcomas.

Results

Sarcomas associated with a clinically identified genetic disease represent 2.8% out of all cases.
Most of these cases (14/19) are related to Recklinghausen neurofibromatosis.
Radiation-induced sarcomas represent 3.3% out of all cases.
Most of these cases (9/22) are related to prior breast cancer treatment.
Only 1 case of Stewart-Treves syndrome was observed.
Liposarcoma is not associated with any particular aetiological entity.
Most of the adult soft tissue sarcomas are not related to any classical clinically identified genetic disease or previous radiation therapy and/or chronic lymphoedema risk factors.

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