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See Latest ArticlesBreast cancer biology: the multifaceted roles of mesenchymal stem cells
Journal of Oncology, 06/11/09
Patel SA et al. - In a review of the multifaceted roles of mesenchymal stem cells in breast cancer biology, this article brings attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology.
Methods- Recent upsurge in the interest of breast cancer metastasis is partly attributed to discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment.
- This article discusses the significance of interactions between breast cancer cells and cells of the bone marrow.
- This is a subject of intense research studies aim to provide new methods of treatments and perhaps identification of new drug targets.
- This review discusses the role of inflammation and the bimodal function of the transforming growth factor-β signaling pathway in the process of tumorigenesis.
- This article discusses the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions.
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