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Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects
International Journal of Cancer, 06/11/09

McColgan P et al. - In a study to examine polymorphisms of matrix metalloproteinases (MMP) 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer (CRC) in over 30,000 subjects, it appears that there may be a genetic influence in development of CRC and lung cancer. Subjects with the MMP-1 nt-1607 polymorphism have an increased association with CRC. Those homozygous for either the MMP-2/1306T or 735T allele may be at reduced risk of lung cancer, although the evidence base is small.

• A comprehensive genetic meta-analysis was done of all MMP genes investigated using an allelic-association case-control model in the 3 major cancers of lung, breast and CRC.
• Electronic databases were searched until and including July 2008 for any MMP genetic association study in lung, breast, and CRC.
• Odds ratio (OR) and 95% confidence intervals (CI) were determined for each gene disease association using fixed and random effect models.

• 25 studies addressing 5 polymorphisms in 4 genes were analyzed among 30,651 individuals (15,328 cases and 15,253 controls).
• The MMP-1 nt-1607 polymorphism was significantly associated with CRC in both the dominant and recessive models.
• MMP-21306CT and 735CT were significantly associated with protection against lung cancer.
• No association was found with the MMP 1, 2, 3 or 9 polymorphisms with breast cancer, MMP-1, 3, or 9 with lung cancer or MMP-2, 3 or 9 with CRC.

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