Oncology Medical News about effects of irradiation;hypoxia;impact of erythropoietin

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Impact of erythropoietin on the effects of irradiation under hypoxia
Journal of Cancer Research & Clinical Oncology, 06/09/09

Lo Nigro C et al. - In a study to experimentally examine the relationship between hypoxia, erythropoietin (EPO), its receptor EPOR, EGFR and their effects on survival and radiosensitivity of head and neck squamous cell carcinoma (HNSCC) cells that underwent hypoxia, it was found that the expression of the EPOR in Cal-166 cells does not seem essential for their growth and that administration of EPO does not affect radiotherapy (RT) efficacy.

Methods

Cal-166 head and neck cell line was used to investigate different cellular responses after RT given in oxic and hypoxic conditions, focusing on the role of EPO administration in cell proliferation and in regulating response to RT.

Results

EPO does not evoke a physiologic response on EPOR-bearing tumor cells as assessed by cellular growth and proliferation.
Some indications were presented that EPO could activate opposite signals related to proliferation, DNA repair, and apoptosis.
Among them, EGFR and AKT phosphorylation may play a role in radioresistance.

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