Oncology Medical News about invasive breast cancer;ER-positive luminal-like subtype;prognostic significance of PELP1 expression

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The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype
Breast Cancer Research and Treatment, 06/09/09

Habashy HO et al. - In a trial to explore clinical and biological relevance of proline, glutamate, and leucine rich protein 1 (PELP1) protein expression in a group of consecutive pts (1162 pts) with invasive breast cancers with particular emphasis on its role in the oestrogen receptors (ER)-positive/luminal-like class of tumours, it was shown that PELP1 protein expression is an independent prognostic predictor of shorter breast cancer specific survival (BCSS) and disease-free survival (DFI) in breast cancer and its elevated expression is positively associated with markers of poor outcome. PELP1 appears to have a potential application in assessing clinical outcome of pts with ER-positive breast cancer.

Methods

Transcription functions of ER are influenced by several coregulators such as PELP1.
This study uses tissue microarrays and immunohistochemistry.

Results

Increased PELP1 expression is associated with tumours of larger size, higher histological grade, higher mitotic count, and with positive expression of basal cytokeratins (CK) (CK14 and CK5/6), P-cadherin, p53, and MIB1.
There was an inverse association between PELP1 expression and ER, progesterone (PgR), androgen (AR) receptor, and luminal CK (CK18) expression.
A significant association between PELP1 expression and shorter BCSS and DFI was found.
Multivariate Cox hazard analysis showed that PELP1 expression was an independent predictor of shorter BCSS and shorter DFI.
In the ER-positive/luminal-like group (n=768), PELP1 expression showed similar association with other clinicopathological variables and was an independent predictor of shorter DFI.

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