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Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
International Journal of Cancer, 06/10/09

Tolstov YL et al. - Although past exposure to MCV is common among all adult groups, MCC patients have a markedly elevated MCV IgG response compared with control patients. The study demonstrates that MCV is a widespread but previously unrecognized human infection.

Exclusive Author Commentary
Yuan Chang, 06/10/09

This test is based on a virus-like particle EIA and is highly specific to MCV without cross-reactivity to other human polyomaviruses. The assay will be useful for assessing MCV infection and for epidemiologic studies designed to identify other diseases associated with MCV. Together with its companion paper describing a monoclonal antibody for detection of MCV T antigen protein expression in tumor cells, these papers demonstrate that MCV is the likely the infectious cause for most Merkel cell carcinomas.

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