Oncology Medical News about vascular endothelial growth factor gene;gastric cancer

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Effect of polymorphisms in the 3′ untranslated region (3′-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan
Molecular Carcinogenesis, 06/08/09

Tahara T et al. – Data suggest that the G1612A, but not C936T polymorphisms in the 3′ untranslated region (3′-UTR) of vascular endothelial growth factor (VEGF) gene is associated with the susceptibility to gastric cancer (GC) in the Japanese population.

Methods

An investigation of the effect of VEGF gene polymorphisms on the risk of GC and peptic ulcer diseases in a Japanese population
The G1612A(rs10434) and C936T(rs3025039) polymorphisms in 3′-UTR of VEGF gene were genotyped
844 subjects including: 385 GC, 143 ulcer including 98 gastric ulcer (GU) 45 duodenal ulcer (DU), and 316 nonulcer subjects

Results

1612A carrier held a higher risk of GC vs both noncancer and nonulcer
1612A carrier was more closely associated with an increased risk of noncardiac cancer, lower third cancer, and Lauren's diffuse-type cancer
Same genotype was not associated with the progression of GC
C936T genotype was not associated with a risk of GC and its progression
Both the G1612A and C936T genotypes were not associated with the risk of peptic ulcer diseases

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