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Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts
Carcinogenesis, 06/05/09

Zibat A et al. - The authors point to key differences in the tumorigenic mechanisms underlying adult and childhood tumors. The latter ones are unique among all tumors since their occurrence decreases rather than increases with age. A better understanding of mechanisms underlying this ontological restriction is of potential therapeutic value.

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Characterization of the metabolic changes underlying growth...