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Radioisotope guided sentinel lymph node dissection in patients with localized prostate cancer: Results of the first 100 cases
European Journal of Surgical Oncology, 06/08/09

Bastide C et al. - Limited pelvic lymph node dissection (PLND) to obturator fossa is clearly insufficient for accurate lymph node staging in patients with prostate cancer (PCa). Sentinel lymph node (SLN) procedure could be an alternative with an excellent sensitivity in patients with unfavorable prognostic factors.

Methods

An assessment of the results and the relevance of radioisotope guided PLND in loco-regional staging in pts with clinically localized PCa
100 pts underwent radioisotope guided PLND
87 pts were candidates for retropubic radical prostatectomy and 13 underwent radiotherapy
72 first pts received 2× 0.3 ml of 30 MBq-nanocolloid-^99mTc
Next 28 received 2× 0.3 ml of 100 MBq
SLNs were detected intraoperatively with a gamma probe

Results

Median number of 3 SLNs was removed per patient
SLNs were located outside obturator fossa in >2/3^rd of pts
Lymph node involvement was observed in 12% of pts
50% of lymph node metastases (LNM) were outside obturator fossa
41.6% of LNM were lying at the first centimeters of the hypogastric artery
11/13 LNM were detected in the SLN
2 non-SLN (NSLN) involved nodes were found in 2 pts who failed the sentinel lymph node procedure
Each of 12 pts had pre-operative PSA above 10 ng/ml and Gleason score ≥7

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Risk of dying from prostate cancer in men randomized to screening
Cancer, 10/13/09 Relevance Score: 72%

Prostate Cancer Specific Mortality and Gleason 7 Disease Differences in Prostate Cancer Outcomes Between Cases With Gleason 4 + 3 and Gleason 3 + 4 Tumors in a Population Based Cohort
The Journal of Urology, 11/20/09 Relevance Score: 71%

A prospective study of lifetime physical activity and prostate cancer incidence and mortality
British Journal of Cancer, 11/02/09 Relevance Score: 71%

Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
The Prostate, 11/02/09 Relevance Score: 71%

Prostate specific antigen for early detection of prostate cancer: longitudinal study
British Medical Journal, 10/08/09 Relevance Score: 71%