Oncology

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The outcomes after surgical resection in pancreatic endocrine tumors: An institutional experience
European Journal of Surgical Oncology, 06/08/09

You DD et al. – Study demonstrates that surgical resection is curative for well-differentiated tumors (WDT) and recurrences are frequent in spite of curative resection for malignant pancreatic endocrine tumors (PET).

• Aim was to analyze surgical outcomes of sporadic PET and factors influencing survival
• Between 1995 and 2007, pts who underwent surgery were retrospectively reviewed for clinicopathologic variables and outcomes according to the WHO classifications

• Total 96 pts:
  • 39 pts had WDT with benign behavior
  • 23 had uncertain behavior
  • 27 had low-grade carcinoma, and
  • 7 were diagnosed with high-grade carcinoma
• R0 resection was performed in 84 pts
• No recurrence was observed in WDT regardless of its behavior or curability
• However, 16/34 pts with carcinoma had recurrence
• 5 yr OS for R0-resected pts with carcinoma was 57%
• OS at 3 yrs for R1/R2-resected pts was 23%
• WHO classification and R0 resection were independent prognostic factors in multivariate analysis

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