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Chemotherapy toxicity in gynecologic cancer patients with a body surface area (BSA) > 2 m2
Gynecologic Oncology, 06/04/09
Schwartz J et al. - Obese women with a BSA > 2 m2 on paclitaxel dosed by ABW do not experience excess toxicity in comparison to women on paclitaxel capped at a maximum BSA or women in published trials of adjuvant P/C. Empiric dose reduction is unnecessary and may result in suboptimal treatment of obese patients. However, as this was a retrospective review, more research is needed to make definitive recommendations on this topic.
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