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Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours
European Journal of Cancer, 06/03/09
Kitzen JJEM et al. - The most frequent haematological side-effect was mild grade 1–2 anaemia. Non-haematological toxicities included fatigue, nausea, vomiting, diarrhoea and constipation, all grade 1–2. Two lethal events were observed in which an increase in caspase-3 activity and overt apoptosis in monocytes and neutrophils could be seen. Pharmacokinetic studies showed high inter-individual variability and rendered F60008 a far from optimal derivate of triptolide.
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Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: A double-blind, randomised trial
The Lancet Oncology - Online First, 12/09/09
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Supportive Care in Cancer, 12/09/09
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