Oncology Medical News about Plexin B1

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Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells
Oncogene, 06/03/09

Argast GM et al. - Plexin B1 has tumor-suppressor function in early-stage cells, although suppressing migration in late-stage cells. The findings suggest that B-Raf/MKK/ERK provides a permissive environment for melanoma genesis by modulating plexin B1.

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