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See Latest ArticlesA Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma
Clinical Cancer Research, 06/03/09
Yip D et al. - The data show that glutamate blockade with riluzole can inhibit signaling through the mitogen-activated protein kinase and phosphatidylinositol 3-kinase/AKT pathways and suppress the metabolic activity of melanoma. The ectopic expression of metabotropic glutamate receptors may be important in the pathogenesis of human melanoma, and targeting this pathway may be an effective therapy.
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Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
Human Pathology, 12/16/09
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