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See Latest ArticlesWounds and survival in cancer patients
European Journal of Cancer, 06/03/09
Maida V et al. - In a study to assess whether certain wound classes affecting cancer pts carry associations with survival, it was found that presence of pressure ulcers (PUs) in female cancer pts and other wounds in all cancer pts correlates with reduced survival. These data should be incorporated into existing prognostic models or used in conjunction with them in order to enhance prognostic accuracy.
Methods- As a prospective observational study, based on a sequential case series of 418 advanced cancer pts, all cutaneous and wound issues were documented and monitored.
- 377 pts were followed until their deaths.
- Univariate and multivariate survival analyses were performed using hazard ratios (HRs) derived from Cox-proportional hazard models.
- 44% of pts presented with at least 1 wound at referral.
- Pts with wounds displayed worse overall survival than those without wounds.
- A significant interaction was seen between PUs and sex.
- After controlling for co-occurrence of wounds, age, sex, Charlson comorbidity index and PPSv2, statistically significant increased risk of death was observed for female pts with PU’s, but not for males.
- Malignant wounds were not associated with decreased survival.
- Presence of all other wounds was associated with decreased survival.
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