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A high proportion of bone marrow T cells with regulatory phenotype (CD4+CD25hiFoxP3+) in Ewing sarcoma patients is associated with metastatic disease
International Journal of Cancer, 06/02/09
Brinkrolf P et al. - Increased BM Treg cells in patients with metastasized ES may reflect an immune escape mechanism that contributes to the development of metastatic disease. Immunotherapeutic strategies will have to adequately consider the regulatory milieu within areas of Ewing tumor-immune interactions.
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Today in Basic Science/Genetics...keeping you current
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Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal-type
Blood, 12/09/09
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome
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TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway
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Today in Soft Tissue/Sarcoma...keeping you current
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High-dose chemotherapy with blood or bone marrow transplants for rhabdomyosarcoma
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