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Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma
Endocrine-Related Cancer, 06/05/09

Durante C et al. - In a study to evaluate the long-term outcome and prognostic factors for survival in pts with distant metastases from gastroenteropancreatic well-differentiated endocrine carcinoma (GEP WDEC), this study enables the stratification of metastatic GEP WDEC pts into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and to design and interpret clinical trials.

Methods

Long-term outcome and prognostic factors for survival were evaluated in 118 pts with distant metastases from GEP WDEC.
Inclusion criteria included pathological review by a single pathologist according to WHO criteria, absence of previous therapy apart from surgery, complete morphological evaluation within 3 mos including somatostatin receptor scintigraphy, and follow-up at Gustave-Roussy Institute until death or study's end.
Clinical, biological marker, and pathological parameters were analyzed in univariate and multivariate statistical models.
Survival after the first complete imaging work-up of the metastatic disease was determined using Kaplan–Meier method.

Results

Survival for 5 yrs after diagnosis of metastatic disease was 54%.
In multivariate analysis, age, number of liver metastases, tumor slope, and initial surgery were predictive of survival.
5-yr survival was 100%, 91%, 62%, and 9% when pts had 0, 1, 2, 3, or more poor prognostic features, respectively.

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