Oncology Medical News about cancer prevention;natural compounds

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Ruhul Amin ARM et al. – This review discusses the promising natural chemopreventive compounds, their molecular targets, and their mechanisms.

Why natural compounds?

Because an ideal chemopreventive agent should be nontoxic, effective at lower doses, economical, and easily available.

Chemopreventive properties of selected promising natural compounds:

Tea polyphenols: Epigallocatechin-3-gallate (EGCG) found in tea, the most abundant polyphenol has anticarcinogenic activity.
Curcumin: Curcumin, isolated from the roots (rhizomes) of the plant Curcuma longa, the major yellow pigment is known for its antitumorigenic activity.
Resveratrol: Resveratrol is a phytoalexin, a major constituent of red wine, and abundant in the grape skin.
Lycopene: A natural antioxidant that imparts red color to tomatoes, guava, rosehip, watermelon, and pink grapefruit is known for its strong antioxidant properties, and has drawn much attention as a cancer preventing agent.
Pomegranate: A number of in vitro and in vivo studies suggest that pomegranate has strong potential for prostate cancer chemoprevention.
Luteolin: A flavonoid abundant in several green vegetables, such as broccoli, celery, cabbage, spinach, green pepper, and cauliflower, exhibits a wide array of pharmacologic properties ranging from anti-inflammation to anticancer effects.
Genistein: A phytoestrogen abundant in soybeans and soy products. An inverse correlation between dietary soy consumption and the risk of prostate, breast, and endometrial cancer is established.