Oncology

Your Article Summary

See Latest Articles

Perspectives for cancer prevention with natural compounds
Journal of Clinical Oncology, 06/01/09

Ruhul Amin ARM et al. – This review discusses the promising natural chemopreventive compounds, their molecular targets, and their mechanisms.

Why natural compounds?

Because an ideal chemopreventive agent should be nontoxic, effective at lower doses, economical, and easily available.

Chemopreventive properties of selected promising natural compounds:

• Tea polyphenols: Epigallocatechin-3-gallate (EGCG) found in tea, the most abundant polyphenol has anticarcinogenic activity.
• Curcumin: Curcumin, isolated from the roots (rhizomes) of the plant Curcuma longa, the major yellow pigment is known for its antitumorigenic activity.
• Resveratrol: Resveratrol is a phytoalexin, a major constituent of red wine, and abundant in the grape skin.
• Lycopene: A natural antioxidant that imparts red color to tomatoes, guava, rosehip, watermelon, and pink grapefruit is known for its strong antioxidant properties, and has drawn much attention as a cancer preventing agent.
• Pomegranate: A number of in vitro and in vivo studies suggest that pomegranate has strong potential for prostate cancer chemoprevention.
• Luteolin: A flavonoid abundant in several green vegetables, such as broccoli, celery, cabbage, spinach, green pepper, and cauliflower, exhibits a wide array of pharmacologic properties ranging from anti-inflammation to anticancer effects.
• Genistein: A phytoestrogen abundant in soybeans and soy products. An inverse correlation between dietary soy consumption and the risk of prostate, breast, and endometrial cancer is established.

Molecular targets for natural chemopreventive agents:

• p53 family members
• Nuclear Factor-Kappa B
• Activator Protein a (AP-1)
• Signal Transducers and Activators of Transcription Pathway (STAT)
• Growth factors and their receptors
• Host factors/Immunoprevention

<< Previous PTEN expression and KRAS mutations on primary tumors and...

Next >> Improved survival in metastatic colorectal cancer is associated...

Related Articles

Preventing future cancers by testing women with ovarian cancer for brca mutations
Journal of Clinical Oncology, 10/22/09    Relevance Score: 71%

Nutrition Guidelines for Cancer Prevention: More Than Just Food for Thought
Geriatrics & Aging, 10/19/09    Relevance Score: 71%

Screening for Cancer
MedLinePlus, 11/02/09    Relevance Score: 70%

FDA Approves Gardasil to Prevent Genital Warts in Males. Agency Also Approves Bivalent HPV Vaccine for Girls, Young Women
American Family Physician, 10/27/09    Relevance Score: 70%

Colorectal cancer incidence and postmenopausal hormone use by type, recency, and duration in cancer prevention study II
Cancer Epidemiology, Biomarkers & Prevention, 10/28/09    Relevance Score: 69%

Today in Alternative Therapies...keeping you current

Receive free subspecialty "5-minute updates" via email

Effectiveness of Traditional Chinese Medicine for Liver Protection and Chemotherapy Completion among Cancer Patients
Evidence-based Complementary and Alternative Medicine , 11/20/09

Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
Cancer Treatment Reviews, 11/19/09

Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells
Medical Oncology, 11/19/09

 See all of Alternative Therapies

Today in Basic Science/Genetics...keeping you current

Receive free subspecialty "5-minute updates" via email

Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells
Oncogene, 11/25/09

A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy
Oncogene, 11/25/09

Embryoid body formation of human amniotic fluid stem cells depends on mTOR
Oncogene, 11/25/09

 See all of Basic Science/Genetics


Sponsor