Oncology Medical News about xeroderma pigmentosum

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Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk
European Journal of Cancer, 06/01/09

Lucca JD et al. - Besides severe deficiencies in translesion synthesis which are major risks factors for skin carcinomas and melanomas, less deleteriousPOLH variants could act as low penetrance melanoma predisposing alleles. The ongoing identification of genetic markers implied in skin cancer predisposition could help to identify high-risk subjects as targets for clinical follow-up. Replication studies in other populations are awaited to assess these data.

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