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Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors
Bulletin du Cancer, 05/29/09

Ouerhani S et al. - The authors data have reported that tobacco\; NAT2, GSTM1 and GSTT1 genotypes were not associated with bladder tumor stage. When they studied the superficial bladder tumor group, they have shown that in smokers tobacco was associated with the development of low-grade tumors. Conversely, non-smoker patients carrying altered NAT2 genotypes were with a 3.67-fold increased risk of developing superficial high-grade tumors.

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