Oncology

Your Article Summary

See Latest Articles

High SUV uptake on FDG–PET/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG–PET/CT staging in lymphoma
Annals of Oncology, 06/02/09

Ngeow JYY et al. - In a trial to compare the value of positron emission tomography (PET)/computed tomography (CT) over conventional CT and bone marrow biopsy (BMB) in the initial evaluation of pts with lymphoma, it was found that PET/CT upstages 17% of cases and detects occult splenic involvement. This may have potential therapeutic and prognostic implications. SUV >10 may predict for an aggressive histology. Except for indolent B-NHL, data show that PET scans have a good overall negative predictive value (NPV) in excluding lymphomatous bone marrow involvement. This is particularly true of early-stage Hodgkin’s lymphoma (HL), suggesting that BMB may be safely omitted in this group.

• Data on 122 pts with PET/CT scans as part of their initial staging were prospectively collected and reviewed.
• All pts had complete staging, including BMB.

• Among the 122 pts, 101 had NHL and 21 had HL.
• Compared with conventional CT, PET/CT upstaged 21 (17%) cases [B-cell NHL (B-NHL), 12; T-cell NHL (T-NHL), 3; HL, 6].
• In 13 pts with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG)-avid splenic lesions, 4 had normal CT findings.
• A maximum FDG uptake of >10 standardized uptake value (SUV) seems to significantly correlate with an aggressive B-cell lineage.
• PET scan was concordant with BMB results in 108 (89%) and discordant in 14 (11%) cases.
• In HL, these data show that PET scan and marrow results agreed in 19 of the cases (90%), being concordantly negative in 18 cases and concordantly positive in 1, giving a negative predictive value (NPV) of 100%, sensitivity of 100% and specificity of 90%.
• Of note, all 13 with early-stage HL had negative PET/CT scan and BMB.
• In NHL, all 17 cases of T-NHL had concordant PET and BMB results.
• In pts with aggressive B-NHL, BMB and PET/CT agreed in 58 pts (92%) and disagreed in 5 (8%), while corresponding rates in indolent B-cell lymphoma were 14 (67%) and 7 pts (33%), respectively.
• All 7 were falsely negative.

Today in Basic Science/Genetics...keeping you current

Receive free subspecialty "5-minute updates" via email

Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09

Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents
Annals of Oncology, 11/02/09

Evaluating the combined effect of comorbidity and prostate-specific antigen kinetics on the risk of death in men after prostate-specific antigen recurrence
Journal of Clinical Oncology, 11/02/09

See All of Basic Science/Genetics