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Lung cancer and lung transplantation: a review
Journal of Thoracic Oncology, 06/05/09

Mathew J et al. - In a review of lung cancer and lung transplantation, it was concluded that treatment for pts with lung cancer in the lung transplant setting has to be individualized because of the complexity of their medical problems and multiple medications. Attention needs to be focused on detecting lung cancer early in these pts to achieve a favorable outcome.

Methods

With the increase in the number of lung transplants, it is expected that there will be a corresponding increase in the number of lung cancers reported in these pts.
Longevity of the transplant recipients, lung transplantation for chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, a history of smoking, and increasing age of the lung donors make lung cancer more likely.

Results

Nodules and masses seen in chest imaging in lung transplant pts call for work up until a final diagnosis is achieved because there is a high likelihood of a serious infection or malignancy.
Presence of a native lung is a major risk factor for lung cancer occurring in the transplant setting.
Lung cancer of donor origin is rare.
Bronchioloalveolar carcinoma confined to 1 lung can potentially be treated by transplanting the affected lung.

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