Oncology Medical News about spherocytosis

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Clinico-hematological profile of hereditary spherocytosis: experience from a tertiary care center in North India
Hematology, 05/28/09

Kar R et al. - Taking the MFI range of 5341·1-10 557·5 for HS, eight cases of suspected HS/undiagnosed hemolytic anemia with a negative or equivocal incubated OFT were diagnosed as HS. An increase in HbF level was seen in 10 cases ranging from 2·1 to 17·7% with a mean of 5·66%, three of these had associated beta thalassaemia trait. Twelve patients (17%) underwent splenectomy and 91% of them did not require any BT post-splenectomy. Among the patients treated conservatively 49% had persisting pallor and 16·3% had transfusion requirement.

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Role of the interaction between Lu/BCAM and the spectrin-based membrane skeleton in the increased adhesion of hereditary spherocytosis red cells to laminin
British Journal of Haematology, 11/11/09 Relevance Score: 84%