Oncology Medical News about non-metastatic osteosarcoma;aggressive treatment;health-related quality of life

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Aggressive treatment of non-metastatic osteosarcoma improves health-related quality of life in children and adolescents
European Journal of Cancer, 05/26/09

Hinds PS et al. – Data show that health-related quality of life (HRQOL) of patients improves during aggressive treatment for non-metastatic osteosarcoma, except in the domain of nausea..

Methods

A prospective study, undertaken to assess:
- treatment effects on pts’ HRQOL at diagnosis, during therapy and after completion of therapy and
- differences between pts’ and parents’ reports
66 pts (median age, 13.4 yrs) with newly diagnosed, localised disease completed 3 HRQOL instruments
Their parents completed 2 of the same instruments at diagnosis, before surgery (wk 12), at wk 23 and 20 wks after treatment completion

Results

Improvements in most domains and worsening of nausea were reported by pts and parents from diagnosis to wks 12 and 23
Symptom distress decreased from diagnosis to wks 12 and 23 in 81% and 64% of pts, respectively
No sex- and few age-related differences in scores
Scores from pts and parents achieved good agreement

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