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See Latest ArticlesNeuroendocrine tumors of the pancreas
The Oncologist, 06/01/09
Ehehalt F et al. - Main objectives of literature review are:
- Assess the basic aspects of pancreatic neuroendocrine tumors (PNET) tumor biology, pathogenesis, and classification
- Explain the epidemiology and evaluate the prognosis of PNET pts
- Engage in rational clinical management of PNETs
- PNETs display variable malignant potential, hormone-related syndromes (functionality), localization, and genetic background
- Optimal clinical management of PNETs involves a multidisciplinary approach:
- Surgery remains the only curative treatment for early-stage disease
- Alternative therapeutic approaches including:
- chemotherapy, radiofrequency ablation, transarterial chemoembolization
- biotherapy, polypeptide radionuclide receptor therapy
- antiangiogenic therapy, and selective internal radiotherapy
have failed to demonstrate a long-term survival benefit
- Research on PNETs is needed to improve the therapeutic options for pts with this disease
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