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Histologic grading of invasive lobular carcinoma: does use of a 2-tiered nuclear grading system improve interobserver variability
Annals of Diagnostic Pathology, 05/28/09
Adams AL et al. - The differences between the 2 were statistically significant. Because histologic grade has significant prognostic implications for patients with breast cancer, accurate reporting is paramount. For ILC, where use of the NHG places substantial weight on nuclear pleomorphism, a 2-tiered nuclear grading system may reduce interobserver variability yet still provide useful prognostic information.
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