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See Latest ArticlesDiagnostic value of decreased expression of CD56 protein in papillary carcinoma of the thyroid gland
Basic and Applied Pathology, 05/26/09
Park WY et al. – Findings suggest that CD56 is a good negative marker for diagnosing papillary carcinoma of the thyroid gland (PC). Immunohistochemical panels directed at the diagnosis of PC should include CD56 together with galectin-3 and CK19.
Methods- Study to compare and evaluate the diagnostic value of CD56, cytokeratin 19 (CK19), and galectin-3 IHC stainings in distinguishing between PC and other thyroid malignancies and benign lesions
- Expressions of the 3 markers were evaluated in PC (n=67), follicular carcinoma (FC, n=23), medullary carcinoma (MC, n=18), anaplastic carcinoma (AC, n=4), follicular adenoma (FA, n=15), and nodular hyperplasia (NH, n=21)
- Significantly different expressions of CD56, galectin-3, and CK19 in PC vs other lesions of the thyroid gland, with the exception of AC was noted
- Sensitivity and specificity of CD56 for diagnosing PC were 92.5% and 86.4%, respectively
- The diagnostic specificity of CD56 was higher vs galectin-3 or CK19 in differentiating PC from other lesions
- However, its sensitivity was lower than that of galectin-3 or CK19
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