Oncology Medical News about aspergillosis

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A prospective, randomised study on the use of well-fitting masks for prevention of invasive aspergillosis in high-risk patients
Annals of Oncology, 05/19/09

Maschmeyer G et al. - Invasive fungal infections were diagnosed in eight patients in either study arm. One patient in each arm died from proven invasive aspergillosis. There was no difference in the use of systemic antifungals. Of patients in the mask group, 65% described the comfort as acceptable, 26% as unpleasant, and 9% as intolerable. This first randomised study on the use of well-fitting masks failed to show a reduction of invasive fungal infections.

Exclusive Author Commentary
G. Maschmeyer, 05/27/09

The issue of effective prophylaxis of mould infections in severely myelosuppressed patients is still unresolved. Prevention of inhalataion of spore-loaded dust should not be neglected as a consequence from this study. Perhaps the combination of preventive measures and antifungal chemoprophylaxis will further reduce the burden of these invasive fungal infections.

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Severe cerebral aspergillosis after liver transplant
Transplant Infectious Disease, 10/14/09 Relevance Score: 85%

Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome
Clinical Microbiology and Infection, 11/17/09 Relevance Score: 82%

Clinical characteristics and treatment outcomes of chronic necrotizing pulmonary aspergillosis: a review of 43 cases
International Journal of Infectious Diseases, 11/13/09 Relevance Score: 82%

Contribution of galactomannan antigen detection in bronchoalveolar lavage to the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies
Chest, 10/20/09 Relevance Score: 82%

Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor
Transplant Infectious Disease, 10/14/09 Relevance Score: 82%