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Influence of palm oil on doxorubicin induced cytotoxicity in normal and tumor cell cultures
Phytotherapy Research, 06/05/09

Postescu ID et al. - The vitamin E of palm oil, unlike most other vegetal fats, consists largely of tocotrienols (TT), products previously reported as having antioxidant and tumor-inhibitory properties. A tocotrienols containing palm oil, in the form of liposomes entrapping dosages of 0.5-0.05 microgTT/mL, was studied in combined treatments with doxorubicin (30 min before drug administration). The IC50 values of doxorubicin, at 24 h, showed that its cytotoxic effects were decreased by palm oil, in a dose effect relationship, in both normal (Hfl-1, Huvec) and tumor (HepG2, Mls) cells.

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