Oncology Medical News about cachectic cancer patients; transdermal fentanyl

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Transdermal fentanyl in cachectic cancer patients
Pain, 05/18/09

Heiskanen T et al. - Fentanyl is an opioid with high lipid solubility, suitable for intravenous, spinal, transmucosal and transdermal administration. The transdermal fentanyl patch has become widely used in the treatment of both malignant and non-malignant chronic pain. The absorption of fentanyl from the patch is governed by the surface area of the patch, by skin permeability and by local blood flow...Plasma fentanyl concentrations adjusted to dose were significantly lower at 48 and 72h in cachectic patients than normal weight patients. The cachectic patients had a significantly thinner upper arm skin fold, but no differences were found in local blood flow, sweating, or skin temperature. Absorption of transdermal fentanyl is impaired in cachectic patients compared with that of normal weight cancer pain patients.

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