Oncology Medical News about Extra-Osseous Ewing Sarcoma

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Extra-osseous Ewing sarcoma
Pediatric Hematology and Oncology, 05/15/09

van den Berg H et al. - In a trial to assess clinical data and data on outcome of extra-osseous Ewing tumors, it was found that nonmetastasized extra-osseous Ewing tumors have a prognosis at least similar to that of osseous Ewing tumors.

Methods

After a search for Ewing tumors in the database of a single institution over a period of 20 yrs, 16 of 192 cases were found to have extra-osseous primary tumors.

Results

Ages at initial diagnosis ranged from 2.5 to 17 yrs.
Follow-up period ranged from 4 mos to 24.8 yrs.
11 pts were treated according to protocols for Ewing tumors, while in 4 cases soft tissue protocols were used.
In a single pt, only surgery was done.
2 pts had progressive disease despite chemotherapy; a third patient had only tumor response on the initial 2 chemotherapy courses.
All 3 pts with initially metastatic disease died.
1 pt developed a second malignancy.
Overall survival at 5 yrs was 75%.
Event-free survival (EFS) at 5 yrs was 68%; for nonmetastatic pts 5-yr EFS was 83%.

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