Oncology Medical News about meningiomas;gene expression profiling;ErbB receptors;Ligands

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Gene expression profiling of ErbB receptors and ligands in human meningiomas
Cancer Investigation, 05/15/09

Laurendeau I et al. - In a study to ascertain the role of ErbB family receptors in meningiomas, it appears that a strong ErbB1-ErbB2 correlation was found. These data might be useful for gene therapy.

Methods

ErbB family receptors mediate major cellular functions implied in tumorigenesis, though their role in meningiomas was not thoroughly studied.
Tumor therapy requires information about molecular alterations, thus expression of ErbB receptor and ligand genes were studied by real-time RT-PCR in different meningioma grades.

Results

Receptors were overexpressed (ErbB1, ErbB2) or underexpressed (ErbB3, ErbB4).
Ligands EGF, TGFA, AREG, DTR, BTD were underexpressed and the neuregulins were overexpressed or underexpressed.

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