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Hybrid SPECT–CT and PET–CT imaging of differentiated thyroid carcinoma
British Journal of Radiology, 05/13/09

Wong KK et al. - In a review of hybrid radioiodine single photon emission CT with integrated CT (131I SPECT–CT) and 2-(fluorine-18)-fluoro-2-deoxy-D-glucose positron emission tomography with integrated CT (FDG PET–CT) imaging of differentiated thyroid carcinoma (DTC), it appears that FDG PET–CT is used to identify tumours with enhanced glucose metabolism and to localise the source of thyroglobulin production. The CT component of this hybrid technology provides anatomic localisation of activity and allows CT-based attenuation correction of PET images.

Methods

Hybrid imaging modalities such as 131I SPECT–CT and FDG PET–CT allow the rapid and efficient fusion of functional and anatomic images, and provide diagnostic information that may influence management decisions in pts with DTC.
Diagnostic localisation and therapy of these tumours are dependent upon their capacity to concentrate radioiodine (131I) via uptake through the sodium–iodide symporter and retention within the tumour.
Prognosis for most pts with DTC is favourable, although controversy exists regarding the role of post-operative 131I therapy in pts at low-risk for disease.

Results

Accurate identification of functional thyroid tissue (benign or malignant) using diagnostic 131I planar scintigraphy complemented by SPECT–CT imaging enables completion of post-operative staging and pt risk stratification prior to 131I therapy administration.

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