Oncology Medical News about malignant gliomas;anti-angiogenic molecularly targeted therapies

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Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas
Oncology (Karger), 05/15/09

Argyriou AA et al. - In a review of angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas, this article examines current knowledge on angiogenesis as a molecular pathogenetic mechanism of malignant gliomas and looks at and discusses antiangiogenic molecularly targeted therapies for brain malignancies.

Methods

Angiogenesis is considered to be a regulating factor of vascular development and growth for malignant gliomas, including glioblastoma multiforme (GBM) and anaplastic astrocytomas.
The mechanism of angiogenesis is primarily mediated by hypoxia through chronic activation of the HIF pathway leading to production of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor.
It can be triggered by genetic factors.

Results

VEGF/VEGFR-2 is the predominant angiogenic signalling pathway in malignant gliomas.
Anti-angiogenic molecularly targeted therapies, including monoclonal antibodies or tyrosine kinase inhibitors (TKIs), are being increasingly adopted for treating GBMs.
This approach is based on the ability of anti-VEGFRs monoclonal antibodies to decrease vascular permeability and perfusion, whereas use of TKIs is mainly based on their capacity to interfere with cell communication, receptor signaling, and growth of tumours.

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