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See Latest ArticlesOpioid-induced proliferation of vascular endothelial cells
Journal of Pain Research, 05/11/09
Leo S et al. - Angiogenesis is an important issue in cancer research and opioids are often used to treat pain in cancer patients. Therefore it is important to know if the use of opioids is associated with an aberrant stimulation of tumor growth triggered by the stimulation of angiogenesis in cancer patients. In this study the authors used endothelial cells known to express the mu3 opioid receptor (MOR3), to evaluate the effects of morphine on angiogenesis. The authors first investigated the effect of morphine on the proliferation of endothelial cells. The authors showed that morphine is able to stimulate vascular endothelial cell proliferation in vitro. This effect of morphine is mediated by the mitogen-activated protein kinase (MAPK) pathway as pre-treatment with PD98059 inhibited this excessive proliferation. Because previous studies indicated nitric oxide (NO) as a downstream messenger the authors investigated the role of NO in the aberrant proliferation of endothelial cells. These data could not confirm these findings using intracellular NO measurements and quantitative fluorescence microscopy. The potential use and pitfalls of opioids in cancer patients is discussed in light of these negative findings.
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Today in Pain Management/Palliative Care...keeping you current
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Planning phase III multi-site clinical trials in palliative care: the role of consecutive cohort audits to identify potential participant populations
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