Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ
Top Ten Searches
brca1 prostate-specific antigen sclc fobt egd bmi dysplasia hematologic ovarian hccYour Article Summary
See Latest ArticlesPhosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
Clinical Cancer Research, 05/04/09
Aziz SA et al. - Expression of p85 and p110 alpha subunits is up-regulated in melanoma, indicating that PI3K is a good drug target. Pretreatment pS6 levels correlated with sensitivity to the PI3K inhibitor, LY294002, whereas PI3K and pAkt did not, suggesting that full activation of the PI3K pathway is needed for sensitivity to PI3K inhibition. pS6 should be evaluated as a predictor of response in melanoma patients treated with PI3K inhibitors, as these drugs enter clinical trials.
Related Articles
Loss of SNF5 expression correlates with poor patient survival in melanoma
Clinical Cancer Research, 10/12/09
Relevance Score: 97%
Slow-growing melanoma: a dermoscopy follow-up study
British Journal of Dermatology, 10/05/09
Relevance Score: 93%
Dormancy of metastatic melanoma
Pigment Cell & Melanoma Research, 11/11/09
Relevance Score: 91%
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma
Journal of Investigative Dermatology, 11/03/09
Relevance Score: 91%
KIT as a Therapeutic Target in Melanoma
Journal of Investigative Dermatology, 10/23/09
Relevance Score: 90%
Today in Dermatologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Depression in hospitalized patients with malignant melanoma treated with interferon-alpha-2b: primary to induced disorders
European Journal of Dermatology, 12/02/09
Immunocryosurgery for basal cell carcinoma: results of a pilot, prospective, open-label study of cryosurgery during continued imiquimod application
Journal of the European Academy of Dermatology and Venereology, 12/02/09
Self-reported screening for skin cancer in Austria
European Journal of Dermatology, 12/02/09
Today in Pharmacology/Therapy...keeping you current
Receive free subspecialty "5-minute updates" via email
ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole
Breast Cancer Research and Treatment, 12/02/09
A novel synthetic iminoquinone, BA-TPQ, as an anti-breast cancer agent: in vitro and in vivo activity and mechanisms of action
Breast Cancer Research and Treatment, 12/02/09
FDA Drug Approval Summary: Bevacizumab (Avastin) as Treatment of Recurrent Glioblastoma Multiforme
The Oncologist, 12/02/09
Sponsor
Article Search
Sponsor
Sponsor