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See Latest ArticlesParafibromin immunohistochemistry enables the late diagnosis of parathyroid cancer
Australian and New Zealand Journal of Surgery, 05/04/09
Suliburk JW et al. – Data suggest that diagnosis of parathyroid cancer may well be missed due to lack of clear histological criteria. Parafibromin immunohistochemistry (PI) in selected cases of parathyroid tumours will enable the accurate diagnosis of parathyroid carcinoma.
Methods- Aim was to examine the impact of PI on achieving a late diagnosis of parathyroid cancer
- A case series with data obtained from the University of Sydney Endocrine Surgical Unit database is presented
- PI was performed on the cases identified
- 3 pts had initial diagnosis of parathyroid adenoma; subsequent PI enabled a late diagnosis of parathyroid carcinoma
- Mean age and sex distribution of 3 pts at initial diagnosis was 38.3 yrs, M : F 2:1
- Mean delay in diagnosis was 22 yrs
- No differences in patient age, sex distribution, serum calcium, and tumour weight between the 3 pts and all other pts who have undergone parathyroidectomy for primary hyperparathyroidism
- At follow-up:
- 1 patient appears cured with a normal serum calcium
- 1 has permanent hypoparathyroidism, and
- 1 has persistent hypercalcaemia with control of serum calcium by Cinacalcet therapy
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