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Erythroid Kruppel-like factor (EKLF) is recruited to the gamm-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives
European Journal of Haematology, 05/04/09
Perrine SP et al. - The findings demonstrate that EKLF, and the co-activator BRG1, previously demonstrated to be required for definitive or adult erythropoietic patterns of globin gene expression, are co-opted by SCFA derivatives to activate the fetal globin genes.
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